HRAS Mutations in Epithelial–Myoepithelial Carcinoma
نویسندگان
چکیده
منابع مشابه
Novel mutations of the HRAS gene and absence of hotspot mutations of the BRAF genes in oral squamous cell carcinoma in a Greek population.
Oral squamous cell carcinoma (OSCC) is the sixth most common cancer in the world. The phosphatidylinositol 3 kinase (PI3K) signalling pathway has been reported to play an important role in OSCC. Since we have previously detected absence of hotspot PIK3CA gene mutations in the Greek population, we hypothesized that BRAF or HRAS may be activated as ...
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Background & Aims: Thyroid cancer is the most common endocrine malignancy. Medullary thyroid carcinoma (MTC) is an aggressive malignant tumor arising from parafollicular cells of the thyroid. MTC occurs in hereditary (25%, hMTC) or sporadic (75%, sMTC) forms. The hMTC form has an autosomal dominant inheritance. RET proto-oncogene mutations, especially the 10, 11, and 16 exones, are associated w...
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15 صفحه اولBRAF, NRAS and HRAS mutations in spitzoid tumours and their possible pathogenetic significance.
BACKGROUND The relationships between so-called spitzoid tumours have proven difficult to understand. OBJECTIVES To address three questions: does spitzoid tumour morphological similarity reflect molecular similarity? Does Spitz naevus progress into spitzoid melanoma? Are ambiguous spitzoid tumours genuine entities? METHODS BRAF, NRAS and HRAS mutations were analysed using single-strand confo...
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De novo heterozygous mutations in HRAS cause Costello syndrome (CS), a condition with high mortality and morbidity in infancy and early childhood due to cardiac, respiratory, and muscular complications. HRAS mutations predicting p.Gly12Val, p.Gly12Asp, and p.Gly12Cys substitutions have been associated with severe, lethal, CS. We report on molecular, clinical, and pathological findings in patien...
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ژورنال
عنوان ژورنال: Head and Neck Pathology
سال: 2013
ISSN: 1936-055X,1936-0568
DOI: 10.1007/s12105-013-0506-4